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A cryo-EM structure of Ex4-D-Ala bound to GLP-1R/Gαs To investigate the receptor-bound conformation of the potent exendin-4 analogue containing D-Ala in place of Gly4 (referred to below as Ex4-D-Ala), we undertook cryo-EM studies of the complex formed by this agonist with the GLP-1R
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